Online-Seminar-Series: Experimental Replication in Animal Trials

The recent discussion on reproducibility of scientific results is particularly relevant for preclinical research with animal models. Within certain research communities there exists some tradition to repeat an experiment three times to demonstrate replicability. However, there are hardly any guidelines about how to plan for such an experimental design and also how to report the results obtained.

In this talk Assoc. Prof. Dr. Florian Frommlet from the Medical University of Vienna will first illustrate the scope of the problem by systematically looking at articles published in an issue of "Immunity". Then he provides a thorough statistical analysis of the "three-time" rule as it is currently often applied in practice and gives some recommendations how to improve on study design and statistical analysis of replicated animal experiments.