3R Days 2021: Philipp Hohensinner - The mouse model in SARS-CoV-2 research Part I: The Betacoronavirus

In a three-part series, MedUni Vienna scientists will talk about the mouse as a model in SARS-CoV-2 research as a case study for implementing the 3Rs. Dr. Philipp Hohensinner, a scientist at the Medical University of Vienna, will begin with an introduction to betacoronaviruses and how the mouse hepatitis virus can serve as a model for SARS-CoV-2 research.

We look forward to it!

Below you will find the corresponding abstract.

Dr. Hohensinner`s talk is scheduled for Scientific Day 1 on Nov. 11, 2021.

Members of the RepRefRed Society get a discount, for more information see the event description!

Here you can read the abstract:

The mouse model in SARS-CoV-2 research Part I: The Betacoronavirus

The current SARS-CoV-2 betacoronavirus is causing a massive pandemic. However, SARS-CoV-2 is not the first betacoronavirus to be infectious for humans. However, beta-coronaviruses are not novel and already several human specific beta coronaviruses were reported. Also in the mouse, the mouse coronavirus or better known as mouse hepatitis virus is a beta coronavirus. The mouse specific strain is already known since the 1950ies and has been extensively studied. In this talk we will discuss similarities and differences between mouse and human virus and caused symptoms. We will further define to what extent the mouse virus can be used as a model system to allow for drug development and testing.