3R Days 2021: Roberto Plasenzotti - The mouse model in SARS-CoV-2 research Part III: Host specific viral infection models and how to implement the 3Rs

Building on the first two presentations in the series "The mouse model in SARS-CoV-2 research", Dr. Roberto Plasenzotti, Head of the Department for Laboratory Animal Science and Genetics at the Medical University of Vienna, will explain how the 3Rs can be incorporated into these infection models and why the use of species-specific viruses may be a better approach than infecting transgenic animals with human strains.

We look forward to it!

Below you will find the corresponding abstract.

Dr. Plasenzotti`s talk is scheduled for Scientific Day 1 on Nov. 11, 2021.

Members of the RepRefRed Society get a discount, for more information see the event description!

Here you can read the abstract:

The mouse model in SARS-CoV-2 research Part III: Host specific viral infection models and how to implement the 3Rs

Most zoonotic viral diseases have genetically closely related strains in various mammalian species. In contrast to infecting genetically modified species with human-derived viruses, the use of animal models with the species-specific viruses can lead to a reduction in animal suffering while increasing reproducibility.

Conducting infection experiments does not necessarily mean severe animal suffering, but can be minimized by using the appropriate model and appropriate refinement measures. This presentation builds on the previous two and will provide insight into how the 3Rs can best be considered in these infection models.