Biological Variation and Reproducibility
During the 3Rs days, Dr. Bernhard Voelkl from the University of Bern gave a presentation of his work on reproducibility issues in animal experiments and how these can be counteracted2,3. Together with Prof. Hanno Würbel, a video has been produced as part of this work through support from the Swiss National Science Foundation, the NC3Rs and the European Research Council, which is intended to illustrate the problem and show researchers possible solutions for their own projects.
You can watch the video below! For further information or questions regarding the publications, you can use the provided information at the end of the article.
1 Baker, M. 1,500 scientists lift the lid on reproducibility. Nature 533, 452–454 (2016). https://doi.org/10.1038/533452a
2 Voelkl, B., Altman, N.S., Forsman, A. et al. Reproducibility of animal research in light of biological variation. Nat Rev Neurosci 21, 384–393 (2020). https://doi.org/10.1038/s41583-020-0313-3
3 Voelkl, B., Würbel, H., Krzywinski, M. et al. The standardization fallacy. Nat Methods 18, 5–7 (2021). https://doi.org/10.1038/s41592-020-01036-9